4-Hydroxypropranolol hydrochloride
Cat. No.：YN320062
CAS No. ：14133-90-5
| 产品名称: | 4-Hydroxypropranolol hydrochloride |
| CAS No.: | 14133-90-5 |
| Chemical Name: | 4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]-1-naphthalenol, monohydrochloride |
| Synonyms: | (±)-4-hydroxy Propranolol hydrochloride |
| 分子量: | 311.80 |
| 分子式: | C₁₆H₂₂ClNO₃ |
| SMILES: | OC1=C2C=CC=CC2=C(OCC(O)CNC(C)C)C=C1.Cl[H] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 4-Hydroxypropranolol hydrochloride 是 Propranolol 的活性代谢产物。4-Hydroxypropranolol hydrochloride 的效力与 Propranolol 相当。4-Hydroxypropranolol hydrochloride 抑制 β1-和 β2-肾上腺素能受体，pA2值分别为 8.24 和 8.26。4-Hydroxypropranolol hydrochloride 具有固有的拟交感活性，膜稳定活性和强效的抗氧化性能。 |
| IC50和靶点: | |
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Fitzgerald, J.D., and O'Donnell, S.R.Pharmacology of 4-hydroxypropranolol, a metabolite of propranololBrit. J. Pharmacol.43(1),222-235(1971)
Yoshimoto, K., Echizen, H., Chiba, K., et al.Identification of human CYP isoforms involved in the metabolism of propranolol enantiomers–N-desisopropylation is mediated mainly by CYP1A2Br. J. Clin. Pharmacol.39(4),421-431(1995)
Fitzgerald, J.D., and O'Donnell, S.R.A comparison of the haemodynamic effects of propranolol, 4-hydroxypropranolol and practolol in anaesthetized dogsBrit. J. Pharmacol.45(2),207-217(1972)
Mak, I.T., and Weglicki, W.B.Potent antioxidant properties of 4-hydroxyl-propranololJ. Pharmacol. Exp. Ther.308(1),85-90(2004)
