RS 17053 hydrochloride
Cat. No.：YN320133
CAS No. ：169505-93-5
| 产品名称: | RS 17053 hydrochloride |
| CAS No.: | 169505-93-5 |
| Chemical Name: | 5-chloro-N-[2-[2-(cyclopropylmethoxy)phenoxy]ethyl]-α,α-dimethyl-1H-indole-3-ethanamine, monohydrochloride |
| Synonyms: | RS-17053 |
| 分子量: | 449.41 |
| 分子式: | C₂₄H₃₀Cl₂N₂O₂ |
| SMILES: | [H]Cl.ClC1=CC2=C(NC=C2CC(C)(C)NCCOC3=CC=CC=C3OCC4CC4)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | RS 17053 hydrochloride 是一种有效的α1A肾上腺素受体 (α1Aadrenoceptor)的选择性拮抗剂，其在细胞膜中测得的pKi值为 9.1，功能分析的pA2值为 9.8。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Kenny, B.A., Miller, A.M., Williamson, I.J.R., et al.Evaluation of the pharmacological selectivity profile of α1 adrenoceptor antagonists at prostatic α1 adrenoceptors: Binding, functional and in vivo studiesBr. J. Pharmacol.118(4),871-878(1996)
Ford, A.P.D.W., Arrendondo, N.F., Blue, D.R., Jr., et al.RS-17053 (N-[2-(2-cyclopropylmethoxyphenoxy)ethyl]-5-chloro-α, α-dimethyl-1H-indole-3-ethanamine hydrochloride), a selective α1A-adrenoceptor antagonist, displays low affinity for functional α1-adrenoceptors in human prostate: Implications for adrenoceptor classificationMol. Pharmacol.49(2),209-215(1996)
Qi, X., Weizhong, Z., Zhizhen, L., et al.α1A-adrenergic receptor mediated pressor response to phenylephrine in anesthetized ratSci. China C. Life Sci.47(1),59-65(2004)
