Batefenterol
Cat. No.：YN320671
CAS No. ：743461-65-6
| 产品名称: | Batefenterol |
| CAS No.: | 743461-65-6 |
| Chemical Name: | N-[1,1'-biphenyl]-2-yl-carbamic acid, 1-[3-[[2-chloro-4-[[[(2R)-2-(1,2-dihydro-8-hydroxy-2-oxo-5-quinolinyl)-2-hydroxyethyl]amino]methyl]-5-methoxyphenyl]amino]-3-oxopropyl]-4-piperidinyl ester |
| Synonyms: | GSK961081; TD-5959 |
| 分子量: | 740.24 |
| 分子式: | C₄₀H₄₂ClN₅O₇ |
| SMILES: | O=C(OC1CCN(CCC(NC2=CC(OC)=C(CNC[C@H](O)C3=CC=C(O)C4=C3C=CC(N4)=O)C=C2Cl)=O)CC1)NC5=CC=CC=C5C6=CC=CC=C6 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Batefenterol (GSK961081;TD-5959)是一种新的muscarinic受体拮抗剂和β2-肾上腺素受体激动剂; 对hM2，hM3和β2-肾上腺素受体有高亲和力，Ki值分别为1.4, 1.3和3.7nM。 |
| IC50和靶点: | |
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Hedge, S.S., Hughes, A.D., Chen, Y., et al.Pharmacologic characterization of GSK-961081 (TD-5959), a first-in-class inhaled bifunctional bronchodilator possessing muscarinic receptor antagonist and β2-adrenoceptor agonist properties.J. Pharmacol. Exp. Ther.351(1),190-199(2014)
Hughes, A.D., Chen, Y., Hegde, S.S., et al.Discovery of (R)-1-(3-((2-chloro-4-(((2-hydroxy-2-(8-hydroxy-2-oxo-1,2-dihydroquinolin-5-yl)ethyl)amino)methyl)-5-methoxyphenyl)amino)-3-oxopropyl)piperidin-4-yl [1,1'-biphenyl]-2-ylcarbamate (TD-5959, GSK961081, batefenterol): First-in-class dual pharmacology multivalent muscarinic antagonist and β2 agonist (MABA) for the treatment of chronic obstructive pulmonary disease (COPD)J. Med. Chem.58(6),2609-2622(2015)
