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ICI 118,551 hydrochloride

Cat. No.:YN320811

  • CAS No. :72795-01-8

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    • 产品名称: ICI 118,551 hydrochloride
      CAS No.: 72795-01-8
      Chemical Name: (2R,3R)-rel-1-[(2,3-dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanol, monohydrochloride
      Synonyms:ICI 118551 hydrochloride
      分子量:313.86
      分子式:C₁₇H₂₈ClNO₂
      SMILES:CC1=C(CCC2)C2=C(OC[C@H](O)[C@@H](C)NC(C)C)C=C1.[H]Cl
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: ICI 118,551 hydrochloride 是一种高度选择性的β2 adrenergic receptor拮抗剂,结合 β2,β1 和 β3 肾上腺素能受体的Ki值分别为 0.7,49.5 和 611 nM。
      IC50和靶点:
      In Vitro:
      In Vivo:
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      Solvent & Solubility:
    • Hoffmann, C., Leitz, M.R., Oberdorf-Maass, S., et al.Comparative pharmacology of human β-adrenergic receptor subtypes—characterization of stably transfected receptors in CHO cellsN.-S. Arch. Pharmacol.369(2),151-159(2004)

      Baker, J.G.The selectivity of β-adrenoceptor antagonists at the human β1, β2 and β3 adrenoceptorsBr. J. Pharmacol.144(3),317-322(2005)

      Deighton, N.M., Motomura, A., Bals, S., et al.Characterization of theβadrenoceptor subtype(s) mediating the positive inotropic effects of epinine, dopamine, dobutamine, denopamine and xamoterol in isolated human right atriumJ. Pharmacol. Exp. Ther.262(2),532-538(1992)

      Rothwell, N.J., Stock, M.J., and Sudera, D.K.Changes in tissue blood flow and β-receptor density of skeletal muscle in rats treated with the β2-adrenoceptor agonist clenbuterolBr. J. Pharmacol.90(3),601-607(1987)

      Kim, I.M., Tilley, D.G., Chen, J., et al.β-blockers alprenolol and carvedilol stimulate β-arrestin-mediated EGFR transactivationProc. Natl. Acad. Sci. USA105(38),14555-14560(2008)

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