Guanfacine hydrochloride
Cat. No.：YN321134
CAS No. ：29110-48-3
| 产品名称: | Guanfacine hydrochloride |
| CAS No.: | 29110-48-3 |
| Chemical Name: | N-(aminoiminomethyl)-2,6-dichloro-benzeneacetamide, monohydrochloride |
| Synonyms: | 盐酸胍法辛 |
| 分子量: | 282.55 |
| 分子式: | C₉H₁₀Cl₃N₃O |
| SMILES: | O=C(NC(N)=N)CC1=C(Cl)C=CC=C1Cl.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Guanfacine hydrochloride 是α2A肾上腺素受体激动剂，Kd为31 nM，具有抗高血压的活性。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Jasper, J.R., Lesnick, J.D., Chang, L.K., et al.Ligand efficacy and potency at recombinant α2 adrenergic receptors: Agonist-mediated [35S]GTPγS bindingBiochem. Pharmacol.55(7),1035-1043(1998)
Nikolic, K., Filipic, S., and Agbaba, D.QSAR study of imidazoline antihypertensive drugsBioorg. Med. Chem.16(15),7134-7140(2008)
Scholtysik, G.Pharmacology of guanfacineBr. J. Clin. Pharmacol.10(Suppl 1),21S-24S(1980)
Kauser, H., Sahu, S., Kumar, S., et al.Guanfacine is an effective countermeasure for hypobaric hypoxia-induced cognitive declineNeuroscience254,110-119(2013)
