Salmeterol xinafoate
Cat. No.：YN321139
CAS No. ：94749-08-3
| 产品名称: | Salmeterol xinafoate |
| CAS No.: | 94749-08-3 |
| Chemical Name: | 4-hydroxy-α1-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-1,3-benzenedimethanol, 1-hydroxy-2-naphthalenecarboxylic acid |
| Synonyms: | 沙美特罗昔萘酸酯; GR 33343X xinafoate |
| 分子量: | 603.75 |
| 分子式: | C₃₆H₄₅NO₇ |
| SMILES: | O=C(C1=CC=C2C=CC=CC2=C1O)O.OC3=C(CO)C=C(C(CNCCCCCCOCCCCC4=CC=CC=C4)O)C=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Salmeterol xinafoate 是长效 β2 肾上腺素能受体 (β2AR) 激动剂，对WT β2AR的Ki值为 1.5 nM。 |
| IC50和靶点: | [{name:"β2 adrenoceptor:9.6 (pEC50)"},{name: "β1 adrenoceptor:6.1 (pEC50)"},{name: "β3 adrenoceptor:5.9 (pEC50)"}] |
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Procopiou, P.A., Barrett, V.J., Ford, A.J., et al.The discovery of long-acting saligenin β2 adrenergic receptor agonists incorporating a urea groupBioorg. Med. Chem.19(20),6026-6032(2011)
Ball, D.I., Brittain, R.T., Coleman, R.A., et al.Salmeterol, a novel, long-acting β2-adrenoceptor agonist: Characterization of pharmacological activity in vitro and in vivoBr. J. Pharmacol.104(3),665-671(1991)
Isin, B., Estiu, G., Wiest, O., et al.Identifying ligand binding conformations of the β2-adrenergic receptor by using its agonists as computational probesPLoS One7(12),e50186(2012)
