L755507
Cat. No.：YN321215
CAS No. ：159182-43-1
| 产品名称: | L755507 |
| CAS No.: | 159182-43-1 |
| Chemical Name: | 4-[[(hexylamino)carbonyl]amino]-N-[4-[2-[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino]ethyl]phenyl]-benzenesulfonamide |
| Synonyms: | Benzenesulfonamide,4-[[(hexylamino)carbonyl]amino]-N-[4-[2-[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino]ethyl]phenyl]-;Benzenesulfonamide,4-[[(hexylamino)carbonyl]amino]-N-[4-[2-[[(2S)-2-hydroxy-3-(4-hydroxyphenox...;L755,507;L-755,507;L-755,507,4-[[ |
| 分子量: | 584.73 |
| 分子式: | C₃₀H₄₀N₄O₆S |
| SMILES: | O=S(C1=CC=C(NC(NCCCCCC)=O)C=C1)(NC2=CC=C(CCNC[C@H](O)COC3=CC=C(O)C=C3)C=C2)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | L755507 是一个有效的, 选择性强的β3-AR激动剂, 其IC50值为 35 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Parmee, E.R., Ok, H.O., Candelore, M.R., et al.Discovery of L-755,507: A subnanomolar humanβ3 adrenergic receptor agonistBioorg. Med. Chem. Lett.8(9),1107-1112(1998)
Yu, C., Liu, Y., Ma, T., et al.Small molecules enhance CRISPR genome editing in pluripotent stem cellsCell Stem Cell16(2),142-147(2015)
Sato, M., Hutchinson, D.S., Evans, B.A., et al.The β3-adrenoceptor agonist 4-[[(Hexylamino)carbonyl]amino]-N-[4-[2-[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino]ethyl]-phenyl]-benzenesulfonamide (L755507) and antagonist (S)-N-[4-[2-[[3-[3-(acetamidomethyl)phenoxy]-2-hydroxypropyl]amino]-ethyl]phenyl]benzenesulfonamide (L748337) activate different signaling pathways in Chinese hamster ovary-K1 cells stably expressing the human β3-adrenoceptorMol. Pharmacol.74(5),1417-1428(2008)
