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Propranolol hydrochloride

Cat. No.:YN321537

  • CAS No. :318-98-9

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    • 产品名称: Propranolol hydrochloride
      CAS No.: 318-98-9
      Chemical Name: 1-[(1-methylethyl)amino]-3-(1-naphthalenyloxy)-2-propanol, monohydrochloride
      Synonyms:盐酸普萘洛尔
      分子量:295.80
      分子式:C₁₆H₂₂ClNO₂
      SMILES:OC(CNC(C)C)COC1=CC=CC2=CC=CC=C12.Cl
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: Propranolol hydrochloride 是一种非选择性的β-adrenergic receptor (βAR)拮抗剂,对 β1AR 和 β2AR 具有高亲和力,Ki值分别为 1.8 nM 和 0.8 nM。Propranolol hydrochloride 抑制 [3H]-DHA 与大鼠脑膜制剂的结合,IC50为 12 nM。Propranolol hydrochloride 可以用于高血压,嗜铬细胞瘤,心肌梗塞,心律不齐,心绞痛和肥大心肌病的相关研究。
      IC50和靶点:
      In Vitro:
      In Vivo:
      Clinical Trial:
      Solvent & Solubility:
    • Baker, J.G.The selectivity of β-adrenoceptor antagonists at the human β1, β2 and β3 adrenoceptorsBr. J. Pharmacol.144(3),317-322(2005)

      Fitzgerald, J.D., and O'Donnell, S.R.A comparison of the haemodynamic effects of propranolol, 4-hydroxypropranolol and practolol in anaesthetized dogsBrit. J. Pharmacol.45(2),207-217(1972)

      Basil, B., Jordan, R., Loveless, A.H., et al.A comparison of the experimental anti-arrhythmic properties of acebutolol (M and B 17,803), propranolol and practololBr. J. Pharmacol.50(3),323-333(1974)

      Costain, D.W., and Green, A.R.β-Adrenoceptor antagonists inhibit the behavioural responses of rats to increased brain 5-hydroxytryptamineBr. J. Pharmacol.64(2),193-200(1978)

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