Ajmalicine
Cat. No.：YN321740
| 产品名称: | Ajmalicine |
| CAS No.: | 483-04-5 |
| Chemical Name: | (19α)-16,17-didehydro-19-methyl-oxayohimban-16-carboxylic acid, methyl ester |
| Synonyms: | Raubasine |
| 分子量: | 352.43 |
| 分子式: | C₂₁H₂₄N₂O₃ |
| SMILES: | O=C(C1=CO[C@@H](C)[C@](CN2CC3)([H])[C@]1([H])C[C@@]2([H])C4=C3C5=CC=CC=C5N4)OC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Ajmalicine (Raubasine) 阿吗里新，长春花草药中发现，是一种降压试剂，用于研究高血压，降低外周阻力和血压。_x000D_Ajmalicine 是一种肾上腺素能试剂，优先阻断 α1-肾上腺素受体alpha 1-adrenoceptor。Ajmalicine (Raubasine) 是一种可逆的非竞争性尼古丁受体拮抗剂 (IC50=72.3 μM)。_x000D_Ajmalicine 优先作用于突触后部位，竞争性拮抗去甲肾上腺素对突触后 α 肾上腺素受体的作用 (pA2=6.57), 竞争 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Sharma, V., Chaudhary, S., Srivastava, S., et al.Characterization of variation and quantitative trait loci related to terpenoid indole alkaloid yield in a recombinant inbred line mapping population of Catharanthus roseusJ. Genet.91(1),49-69(2012)
Srivastava, A., Tripathi, A.K., Pandey, R., et al.Quantitative determination of reserpine, ajmaline, and ajmalicine in Rauvolfia serpentina by reversed-phase high-performance liquid chromatographyJ. Chromatogr. Sci.44(9),557-560(2006)
Demichel, P., Gomond, P., and Roquebert, J.α-Adrenoceptor blocking properties of raubasine in pithed ratsBr. J. Pharmacol.77(3),449-454(1982)
Ruffolo, R.R., Jr., Bondinell, W., and Hieble, J.P.α- and β-adrenoceptors: From the gene to the clinic. 2. Structure-activity relationships and therapeutic applicationsJ. Med. Chem.38(19),3681-3716(1995)
Cahn, R., and Cahn, J.Curative effect of an almitrine-raubasine combination in the postischemic syndrome following transient cerebral ischemia in dogsPharmacology36(3),156-165(1988)
