PF-06685249

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PF-06685249

Cat. No.：YN310427

CAS No. ：1467059-70-6

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产品名称:	PF-06685249
CAS No.:	1467059-70-6
Chemical Name:	6-chloro-5-[6-(dimethylamino)-2-methoxy-3-pyridinyl]-1H-indole-3-carboxylic acid
Synonyms:	PF-249
分子量:	345.78006
分子式:	C17H16ClN3O3
SMILES:	O=C(C1=CNC2=C1C=C(C3=C(OC)N=C(N(C)C)C=C3)C(Cl)=C2)O
存储:	Please store the product under the recommended conditions in theCertificate of Analysis.
运输:	Room temperature in continental US; may vary elsewhere.

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Purity: 98%

产品描述:	PF-06685249 (PF-249) 是一种有效的、具有口服活性的变构AMPK激活剂，对重组AMPK α1β1γ1的EC50为 12 nM。PF-06685249 可用于糖尿病肾病研究。
IC50和靶点:	[{name:"AMPK α1β1γ1:12 nM (EC50)"}]
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Salatto, C.T., Miller, R.A., Cameron, K.O., et al.Selective activation of AMPK β1-containing isoforms improves kidney function in a rat model of diabetic nephropathyJ. Pharmacol. Exp. Ther.361(2),303-311(2017)
Ryder, T.F., Calabrese, M.F., Walker, G.S., et al.Acyl glucuronide metabolites of 6-chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic acid (PF-06409577) and related indole-3-carboxylic acid derivatives are direct activators of adenosine monophosphate-activated protein kinase (AMPK)J. Med. Chem.61(16),7273-7288(2018)

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