Crotonoside
Cat. No.：YN440420
CAS No. ：1818-71-9
规格
价格(RMB)
库存
| 产品名称: | Crotonoside |
| CAS No.: | 1818-71-9 |
| Chemical Name: | 2,3-dihydro-2-oxo-adenosine |
| Synonyms: | 巴豆苷; Isoguanosine |
| 分子量: | 283.24 |
| 分子式: | C₁₀H₁₃N₅O₅ |
| SMILES: | OC[C@@H]1[C@H]([C@H]([C@H](N2C=NC(C(N)=N3)=C2NC3=O)O1)O)O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Crotonoside is isolated from Chinese medicinal herb, Croton. Crotonoside inhibitsFLT3andHDAC3/6, exhibits selective inhibition in acute myeloid leukemia (AML) cells. Crotonoside could be a promising new lead compound for the treatment of AML. |
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Kim, J.H., Lee, S.J., Han, Y.B., et al.Isolation of isoguanosine from Croton tiglium and its antitumor activityArch. Pharm. Res.17(2),115-118(1994)
Fuhrman, F.A., and Fuhrman, G.J.Effects of some naturally-occurring purine ribosides on purinergic receptors in cardiac and smooth muscleComp. Biochem. Physiol. C72(2),203-210(1982)
Ewing, P.L., Schlenk, F., and Emerson, G.A.Comparison of smooth muscle effects of crotonoside (isoguanosine) and adenosineJ. Pharmacol. Exp. Ther.97(3),379-383(1949)
Bullinger, D., Neubauer, H., Fehm, T., et al.Metabolic signature of breast cancer cell line MCF-7: Profiling of modified nucleosides via LC-IT MS couplingBMC Biochem.8,25(2007)
