Toyocamycin
Cat. No.：YN250089
CAS No. ：606-58-6
| 产品名称: | Toyocamycin |
| CAS No.: | 606-58-6 |
| Chemical Name: | 4-Amino-7-β-D-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile; |
| Synonyms: | 丰加霉素; Vengicide |
| 分子量: | 291.26 |
| 分子式: | C₁₂H₁₃N₅O₄ |
| SMILES: | O[C@H]1[C@@H](O[C@H](CO)[C@H]1O)N2C3=C(C(N)=NC=N3)C(C#N)=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Toyocamycin (Vengicide) 是放线菌类产生的腺苷类似物，为 X 盒结合蛋白 1 (XBP1) 抑制剂，抑制 IRE1α 诱导的 ATP 依赖性 XBP1 mRNA 的断裂，IC50值为 80 nM。Toyocamycin (Vengicide) 诱导凋亡，对 IRE1α 的自身磷酸化没有作用。 |
| IC50和靶点: | [{name:"CDK9/cyclinT1:79 nM (IC50)"},{name: "CDK7/Mat1/cyclinH1:2.8 μM (IC50)"},{name: "CDK2/cyclinA:0.67 μM (IC50)"},{name: "Cdk4/cyclin D3:15 μM (IC50)"},{name: "cdk6/cyclin D3:>10 μM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Shentu, X., et al.: J. Antibiot., 69, 406 (2016), Ranatunga, S., et al.: J. Med. Chem., 57, 4289 (2014)
