5-Azacytidine
Cat. No.：YN250126
CAS No. ：320-67-2
| 产品名称: | 5-Azacytidine |
| CAS No.: | 320-67-2 |
| Chemical Name: | 4-amino-1-β-D-ribofuranosyl-1,3,5-triazin-2(1H)-one |
| Synonyms: | 5-氮杂胞苷; Azacitidine; 5-AzaC; Ladakamycin |
| 分子量: | 244.20 |
| 分子式: | C₈H₁₂N₄O₅ |
| SMILES: | OC[C@H]1O[C@@H](N2C(N=C(N)N=C2)=O)[C@H](O)[C@@H]1O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 5-Azacytidine (Azacitidine; 5-AzaC; Ladakamycin) 是胞苷核苷类似物，特异型抑制 DNA 甲基化。5-Azacytidine 与 DNA 结合共价捕获 DNA甲基转移酶 (DNA methyltransferases)，有益于逆转表观遗传变化。5-Azacytidine 诱导细胞自噬 (autophagy)。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Brueckner, B., Boy, R.G., Siedlecki, P., et al.Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of human DNA methyltransferasesCancer Res.65(14),6305-6311(2005)
Esteller, M.Epigenetics in cancerN. Engl. J. Med.358(11),1148-1159(2008)
Lyko, F., and Brown, R.DNA methyltransferase inhibitors and the development of epigenetic cancer therapiesJ. Natl. Cancer Inst.97(20),1498-1506(2005)
Stresemann, C., Brueckner, B., Musch, T., et al.Functional diversity of DNA methyltransferase inhibitors in human cancer cell linesCancer Res.66(5),2794-2800(2006)
