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Ganciclovir

Cat. No.:YN250528

  • CAS No. :82410-32-0

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    • 参考文献
    • 产品名称: Ganciclovir
      CAS No.: 82410-32-0
      Chemical Name: 2-amino-1,9-dihydro-9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]-6H-purin-6-one
      Synonyms:更昔洛韦; BW 759; 2'-Nor-2'-deoxyguanosine
      分子量:255.23
      分子式:C₉H₁₃N₅O₄
      SMILES:O=C1NC(N)=NC2=C1N=CN2COC(CO)CO
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
      Select Batch:
      Purity: 98%
    • 产品描述: Ganciclovir (BW 759) 是一种核苷类似物和口服抗病毒药物,对CMV具有抗病毒活性。Ganciclovir 在体外对疱疹病毒 (herpes group) 和其他一些 DNA 病毒也具有抗病毒活性。Ganciclovir 抑制人类疱疹病毒 (HSV 1 型和 2 型,CMV) 和腺病毒血清型1、2、4、6、8、10、19、22 和 28 的体外复制。Ganciclovir 对猫 1 型疱疹病毒 (FHV-1) 的IC50为 5.2 μM。
      IC50和靶点:
      In Vitro:
      In Vivo:
      Clinical Trial:
      Solvent & Solubility:
    • Balfour, H.H., Jr.Management of cytomegalovirus disease with antiviral drugsRev. Infect. Dis.12(Suppl. 7),S849-S860(1990)

      Bean, B.Antiviral therapy: Current concepts and practicesClin. Microbiol. Rev.5(2),146-182(1992)

      Rasmussen, L., Chen, P.T., Mullenax, J.G., et al.Inhibition of human cytomegalovirus replication by 9-(1,3-dihydroxy-2-propoxymethyl)guanine alone and in combination with human interferonsAntimicrob. Agents Chemother.26(4),441-445(1984)

      Freitas, V.R., Smee, D.F., Chernow, M., et al.Activity of 9-(1,3-dihydroxy-2-propoxymethyl)guanine compared with that of acyclovir against human, monkey, and rodent cytomegalovirusesAntimicrob. Agents Chemother.28(2),240-245(1985)

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