Streptozocin
Cat. No.：YN250563
| 产品名称: | Streptozocin |
| CAS No.: | 18883-66-4 |
| Chemical Name: | 2-deoxy-2-[[(methylnitrosoamino)carbonyl]amino]-D-glucose |
| Synonyms: | 链脲佐菌素; Streptozotocin; U 9889 |
| 分子量: | 265.22 |
| 分子式: | C₈H₁₅N₃O₇ |
| SMILES: | O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](NC(N(C)N=O)=O)[C@H]1O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Streptozocin 是一种抗生素，可使 DNA 甲基化 (DNA-methylating) 。Streptozocin 引起肝脏，肾脏及胰腺 DNA 甲基化，但脑 DNA 中没有甲基化。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Szkudelski, T.The mechanism of alloxan and streptozotocin action in B cells of the rat pancreasPhysiol. Res.50(6),537-546(2001)
Leiter, E.H.Multiple low-dose streptozotocin-induced hyperglycemia and insulitis in C57BL mice: Influence of inbred background, sex, and thymusProc. Natl. Acad. Sci. USA79(2),630-634(1982)
Melmed, R.N., Benitez, C.J., and Holt, S.J.Intermediate cells of the pancreas. III. Selective autophagy and destruction of β-granules in intermediate cells of the rat pancreas induced by alloxan and streptozotocinJ. Cell Sci.13(1),297-315(1973)
Bennett, R.A., and Pegg, A.E.Alkylation of DNA in rat tissues following administration of streptozotocinCancer Res.41(7),2786-2790(1981)
Kramer, J., Moeller, E.L., Hachey, A., et al.Differential expression of GLUT2 in pancreatic islets and kidneys of New and Old World nonhuman primatesAm. J. Physiol. Regul. Integr. Comp. Physiol.296(3),R786-R793(2009)
