Avibactam sodium
Cat. No.：YN250609
| 产品名称: | Avibactam sodium |
| CAS No.: | 1192491-61-4 |
| Chemical Name: | sulfuric acid, mono[(1R,2S,5R)-2-(aminocarbonyl)-7-oxo-1,6-diazabicyclo[3.2.1]oct-6-yl] ester, monosodium salt |
| Synonyms: | 阿维巴坦钠; NXL-104 |
| 分子量: | 287.23 |
| 分子式: | C₇H₁₀N₃NaO₆S |
| SMILES: | O=S(ON1[C@]2([H])CC[C@@H](C(N)=O)[N@@](C2)C1=O)(O[Na])=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Avibactam sodium (NXL-104) 是一种共价，可逆的非β-内酰胺 β-内酰胺酶抑制剂 (β-lactamase) 抑制剂，抑制 β-lactamaseTEM-1和CTX-M-15，IC50分别为 8 nM 和 5 nM。 |
| IC50和靶点: | |
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Stachyra, T., Pe´chereau, M.-C., Bruneau, J.-M., et al.Mechanistic studies of the inactivation of TEM-1 and P99 by NXL104, a novel non-β-lactam β-lactamase inhibitorAntimicrob. Agents Chemother.54(12),5132-5138(2010)
Bonnefoy, A., Dupuis-Hamelin, C., Steier, V., et al.In vitro activity of AVE1330A, an innovative broad-spectrum non-β-lactam β-lactamase inhibitorJ. Antimicrob. Chemother.54(2),410-417(2004)
Lagace´-Wiens, P.R.S., Tailor, F., Simner, P., et al.Activity of NXL104 in combination with beta-lactams against genetically characterized Escherichia coli and Klebsiella pneumoniae isolates producing class A extended-spectrum β-lactamases and class C β-lactamasesAntimicrob. Agents Chemother.55(5),243-247(2011)
King, M., Heil, E., Kuriakose, S., et al.Multicenter study of outcomes with ceftazidime-avibactam in patients with carbapenem-resistant enterobacteriaceae infectionsAntimicrob. Agents Chemother.61(7),1-11(2017)
