Salinomycin
Cat. No.：YN250645
CAS No. ：53003-10-4
| 产品名称: | Salinomycin |
| CAS No.: | 53003-10-4 |
| Chemical Name: | α-ethyl-6-[5-[2-(5-ethyltetrahydro-5-hydroxy-6-methyl-2H-pyran-2-yl)-15-hydroxy-2,10,12-trimethyl-1,6,8-trioxadispiro[4.1.5.3]pentadec-13-en-9-yl]-2-hydroxy-1,3-dimethyl-4-oxoheptyl]tetrahydro-5-methyl-2H-pyran-2-acetic acid |
| Synonyms: | 盐霉素; Procoxacin |
| 分子量: | 751.00 |
| 分子式: | C₄₂H₇₀O₁₁ |
| SMILES: | [H][C@]1([C@](C)(CC2)O[C@]32[C@H](O)C=C[C@]4(O[C@]([H])([C@@H](CC)C([C@@H](C)[C@@H](O)[C@H](C)[C@]5([H])O[C@]([C@@H](CC)C(O)=O)([H])CC[C@@H]5C)=O)[C@@H](C)C[C@H]4C)O3)CC[C@@](CC)(O)[C@H](C)O1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Salinomycin (Procoxacin)，一种钾离子载体抗生素，选择性抑制革兰氏阳性菌的生长 (gram-positive bacteria)。Salinomycin 是Wnt/β-catenin信号传导的有效抑制剂，阻断 Wnt 诱导的 LRP6 磷酸化。Salinomycin (Procoxacin) 选择性抑制人肿瘤干细胞。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Gupta, P.B., Onder, T.T., Jiang, G., et al.Identification of selective inhibitors of cancer stem cells by high-throughput screeningCell138,645-659(2009)
