Camptothecin
Cat. No.：YN250667
| 产品名称: | Camptothecin |
| CAS No.: | 7689-03-4 |
| Chemical Name: | (4S)-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione |
| Synonyms: | 喜树碱; Campathecin; (S)-(+) |
| 分子量: | 348.35 |
| 分子式: | C₂₀H₁₆N₂O₄ |
| SMILES: | O=C1C2=C([C@@](O)(CC)C(OC2)=O)C=C(N1C3)C(C3=C4)=NC5=C4C=CC=C5 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Camptothecin (Campathecin) 是有效的DNA拓扑异构酶 I抑制剂，IC50值为 679 nM。 |
| IC50和靶点: | [{name:"Topoisomerase I:679 nM (IC50)'}, 'Camptothecins'] |
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Drwal, M.N., Agama, K., Wakelin, L.P.G., et al.Exploring DNA topoisomerase I ligand space in search of novel anticancer agentsPLoS One6(9),1-12(2011)
Hsiang, Y.H., Hertzberg, R., Hecht, S., et al.Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase IJ. Biol. Chem.260(27),14873-14878(1985)
Marchand, C., Antony, S., Kohn, K.W., et al.A novel norindeniosoquinoline structure reveals a common interfacial inhibitor paradigm for ternary trapping of the topoisomerase I-DNA covalent complexMol. Cancer Ther.5(2),287-295(2006)
Dancey, J., and Eisenhauer, E.A.Current perspectives on camptothecins in cancer treatmentBr. J. Cancer74(3),327-338(1996)
Rothenberg, M.L.Topoisomerase I inhibitors: Review and updateAnn. Oncol.8(9),837-855(1997)
