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Brefeldin A

Cat. No.:YN250671

  • CAS No. :20350-15-6

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    • 生物活性
    • 参考文献
    • 产品名称: Brefeldin A
      CAS No.: 20350-15-6
      Chemical Name: (1R,2E,6S,10E,11aS,13S,14aR)-1,6,7,8,9,11a,12,13,14,14a-decahydro-1,13-dihydroxy-6-methyl-4H-cyclopent[f]oxacyclotridecin-4-one
      Synonyms:BFA; Cyanein; Decumbin
      分子量:280.36
      分子式:C₁₆H₂₄O₄
      SMILES:O[C@@H]1C[C@]2([H])[C@@](/C=C/CCC[C@H](C)OC(/C=C/[C@H]2O)=O)([H])C1
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: Brefeldin A (BFA) 是一种内酯抗生素,是蛋白质运输的特定抑制剂。Brefeldin A 阻断分泌蛋白和膜蛋白从内质网向高尔基体的转运。Brefeldin A 也是一种自噬 (autophagy) 和mitophagy抑制剂。Brefeldin A 还是一种CRISPR/Cas9激动剂,可抑制HSV-1病毒,并具有抗癌活性。
      IC50和靶点:
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      In Vivo:
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      Solvent & Solubility:
    • Fujiwara, T., Oda, K., Yokota, S., et al.Brefeldin A causes disassembly of the Golgi complex and accumulation of secretory proteins in the endoplasmic reticulumJ. Biol. Chem.263(34),18545-18552(1988)

      Ayala, J.Transport and internal organization of membranes: Vesicles, membrane networks and GTP-binding proteinsJ. Cell Sci.107,753-763(1994)

      Thyberg, J., and Moskalewski, S.Role of microtubules in the organization of the Golgi complexExp. Cell Res.246(2),263-279(1999)

      Klausner, R.D., Donaldson, J.G., and Lippincott-Schwartz, J.Brefeldin A: Insights into the control of membrane traffic and organelle structureJ. Cell Biol.116(5),1071-1080(1992)

      Moss, J., and Vaughan, M.Activation of toxin ADP-ribosyltransferases by eukaryotic ADP-ribosylation factorsMol. Cell. Biochem.193,153-157(1999)

      Vigil, D., Cherfils, J., Rossman, K.L., et al.Ras superfamily GEFs and GAPs: Validated and tractable targets for cancer therapy?Nat. Rev. Cancer10(12),842-857(2010)

      Robinson, D.G., Jiang, L., and Schumacher, K.The endosomal system of plants: Charting new and familiar territoriesPlant Physiol.147,1482-1492(2008)

      Nebenführ, A., Ritzenthaler, C., and Robinson, D.G.Brefeldin A: Deciphering and enigmatic inhibitor of secretionPlant Physiol.130,1102-1108(2002)

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