Caspofungin Acetate
Cat. No.：YN250689
CAS No. ：179463-17-3
| 产品名称: | Caspofungin Acetate |
| CAS No.: | 179463-17-3 |
| Chemical Name: | 1-[(4R,5S)-5-[(2-aminoethyl)amino]-N2-[(10R,12S)-10,12-dimethyl-1-oxotetradecyl]-4-hydroxy-L-ornithine]-5-[(3R)-3-hydroxy-lornithine]-pneumocandin B0 acetate (1:2) |
| Synonyms: | MK-0991 Acetate; L-743872 Acetate |
| 分子量: | 1213.42 |
| 分子式: | C₅₆H₉₆N₁₀O₁₉ |
| SMILES: | OC1=CC=C(C=C1)[C@H]([C@@H]([C@@H]2NC([C@@H]3C[C@H](CN3C([C@H]([C@H](O)C)NC([C@H](C[C@H]([C@@H](NCCN)NC([C@@H]4[C@H](CCN4C([C@H]([C@H](O)CCN)NC2=O)=O)O)=O)O)NC(CCCCCCCCC(CC(CC)C)C)=O)=O)=O)O)=O)O)O.OC(C)=O.OC(C)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Caspofungin Acetate (MK-0991 Acetate) 是一种抗真菌药，能够非竞争性地抑制1，3-β-d葡聚糖合酶的合成。 |
| IC50和靶点: | |
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Letscher-Bru, V., and Herbrecht, R.Caspofungin: The first representative of a new antifungal classJ. Antimicrob. Chemother.51(3),513-521(2003)
Pfaller, M.A., Diekema, D.J., Messer, S.A., et al.In vitro activities of caspofungin compared with those of fluconazole and itraconazole against 3,959 clinical isolates of Candida spp., including 157 fluconazole-resistant isolateAntimicrob. Agents Chemother.47(3),1068-1071(2003)
Perea, S., Gonzalez, G., Fothergill, A.W., et al.In vitro interaction of caspofungin acetate with voriconazole against clinical isolates of Aspergillus sppAntimicrob. Agents Chemother.46(9),3039-3041(2002)
Deresinski, S.C., and Stevens, D.A.CaspofunginClin. Infect. Dis.36(11),1445-1457(2003)
Abruzzo, G.K., Flattery, A.M., Gill, C.J., et al.Evaluation of the echinocandin antifungal MK-0991 (L-743,872): Efficacies in mouse models of disseminated aspergillosis, candidiasis, and cryptococcosisAntimicrob. Agents Chemother.41(11),2333-2338(1997)
