Epothilone B
Cat. No.：YN250697
CAS No. ：152044-54-7
| 产品名称: | Epothilone B |
| CAS No.: | 152044-54-7 |
| Chemical Name: | 7S,11S-dihydroxy-8,8,10R,12S,16R-pentamethyl-3S-[(1E)-1S-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione |
| Synonyms: | EPO 906; Patupilone |
| 分子量: | 507.68 |
| 分子式: | C₂₇H₄₁NO₆S |
| SMILES: | O=C(C[C@H](O)C1(C)C)O[C@H](/C(C)=C/C2=CSC(C)=N2)C[C@]3([H])O[C@]3(C)CCC[C@H](C)[C@H](O)[C@@H](C)C1=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Epothilone B是微管稳定剂，Ki为0.71 μM。 它通过与αβ-微管蛋白异二聚体亚基结合而起作用，导致αβ-微管蛋白解离的减少。 |
| IC50和靶点: | |
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Bollag, D.M., McQueney, P.A., Zhu, J., et al.Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of actionCancer Res.55(11),2325-2333(1995)
Kowalski, R.J., Giannakakou, P., and Hamel, E.Activities of the microtubule-stabilizing agents epothilones A and B with purified tubulin and in cells resistant to paclitaxel (Taxol(R))J. Biol. Chem.272(4),2534-2541(1997)
Goodin, S., Kane, M.P., and Rubin, E.H.Epothilones: Mechanism of action and biologic activityJ. Clin. Oncol.22(10),2015-2025(2011)
