G-418 disulfate
Cat. No.：YN250749
| 产品名称: | G-418 disulfate |
| CAS No.: | 108321-42-2 |
| Chemical Name: | O-2-amino-2,7-dideoxy-D-glycero-α-D-gluco-heptopyranosyl-(1→4)-O-[3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1→6)]-2-deoxy-D-streptamine, disulfate |
| Synonyms: | Geneticin sulfate; Antibiotic G-418 sulfate |
| 分子量: | 692.71 |
| 分子式: | C₂₀H₄₄N₄O₁₈S₂ |
| SMILES: | O=S(O)(O)=O.O[C@@H]([C@@H]1O[C@@]([C@@H]([C@@H](O)[C@@H]2O)N)([H])O[C@]2([H])[C@H](O)C)[C@H]([C@@H](C[C@@H]1N)N)O[C@](OC[C@](C)(O)[C@@H]3NC)([H])[C@@H]3O.O=S(O)(O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | G-418 disulfate 是与 gentamicin B1 的结构相似的氨基糖苷类抗生素，在原核和真核细胞的蛋白质合成过程中，能够阻止蛋白质的延伸阶段，从而抑制蛋白质的合成。 |
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Eustice, D.C., and Wilhelm, J.M.Mechanisms of action of aminoglycoside antibiotics in eucaryotic protein synthesisAntimicrob. Agents Chemother.26(1),53-60(1984)
Bar-Nun, S., Shneyour, Y., and Beckmann, J.S.G-418, an elongation inhibitor of 80 S ribosomesBiochim. Biophys. Acta741(1),123-127(1983)
Giordano-Santini, R., Milstein, S., Svrzikapa, N., et al.An antibiotic selection marker for nematode transgenesisNat. Methods7(9),721-723(2010)
Waitz, J.A., Sabatelli, F., Menzel, F., et al.Biological activity of antibiotic G-418, a new Micromonospora-produced aminoglycoside with activity against protozoa and helminthsAntimicrob. Agents Chemother.6(5),579-581(1974)
