Pentostatin
Cat. No.：YN1441174
| 产品名称: | Pentostatin |
| CAS No.: | 53910-25-1 |
| Chemical Name: | (8R)-3-(2-deoxy-β-D-erythro-pentofuranosyl)-3,4,7,8-tetrahydro-imidazo[4,5-d][1,3]diazepin-8-ol |
| Synonyms: | 喷司他丁; CI-825; Deoxycoformycin |
| 分子量: | 268.27 |
| 分子式: | C₁₁H₁₆N₄O₄ |
| SMILES: | O[C@H]1C(N=CN2[C@H](O[C@@H]3CO)C[C@@H]3O)=C2NC=NC1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Pentostatin (CI-825; Deoxycoformycin) 是一种高效，不可逆的腺苷脱氨酶抑制剂，Ki值为 2.5 pM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Shewach, D.S., Krawczyk, S.H., Acevedo, O.L., et al.Inhibition of adenosine deaminase by azapurine ribonucleosidesBiochem. Pharmacol.44(9),1697-1700(1992)
Tusup, M., Kündig, T.M., and Pascolo, S.Epitranscriptomics modifier pentostatin indirectly triggers Toll-like receptor 3 and can enhance immune infiltration in tumorsMol. Ther.30(3),1163-1170(2022)
Agarwal, R.P.Recovery of 2'-deoxycoformycin-inhibited adenosine deaminase of mouse erythrocytes and leukemia L1210 in vivoCancer Res.39(4),1425-1427(1979)
