HZ-1157
Cat. No.：YN251976
CAS No. ：1009734-33-1
| 产品名称: | HZ-1157 |
| CAS No.: | 1009734-33-1 |
| Chemical Name: | 5-(1,1-dimethylethoxy)-2,4-quinazolinediamine |
| Synonyms: | 5-tert-butoxyquinazoline-2,4-diaMine;HZ-1157;DHFR-inhibitor;5-tert-butoxyquinazoline-2,4-diaMine 2,4-Quinazolinediamine, 5-(1,1-dimethylethoxy)-;5-(tert-Butoxy)quinazoline-2,4-diamine;2,4-Quinazolinediamine, |
| 分子量: | 232.3 |
| 分子式: | C12H16N4O |
| SMILES: | CC(C)(C)OC1=CC=CC2=C1C(N)=NC(N)=N2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | HZ-1157 可抑制HCVNS3/4A 蛋白酶，其IC50值为1.0 μmol/L。HZ-1157 (4a) 对戈登病毒有较高的活性 (EC50= 0.15 μM)，且无明显毒性。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Yu, Y., Jing, J.F., Tong, X.K., et al.Discovering novel anti-HCV compounds with inhibitory activities toward HCV NS3/4A proteaseActa Pharmacol. Sin.35(8),1074-1081(2014)
Chao, B., Tong, X.K., Tang, W., et al.Discovery and optimization of 2,4-diaminoquinazoline derivatives as a new class of potent dengue virus inhibitorsJ. Med. Chem.55(7),3135-3143(2012)
