Gardiquimod
Cat. No.：YN251979
CAS No. ：1020412-43-4
| 产品名称: | Gardiquimod |
| CAS No.: | 1020412-43-4 |
| Chemical Name: | 4-amino-2-[(ethylamino)methyl]-α,α-dimethyl-1H-imidazo[4,5-c]quinoline-1-ethanol |
| Synonyms: | Gardiquimod; |
| 分子量: | 313.4 |
| 分子式: | C17H23N5O |
| SMILES: | NC1=NC2=C(C3=C1N=C(CNCC)N3CC(C)(O)C)C=CC=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Gardiquimod，一种咪唑啉类似物，TLR7/8激动剂。Gardiquimod 可抑制巨噬细胞和活化外周血单个核细胞 (PBMCs) 的HIV-1感染。当浓度低于 10 μM 时，Gardiquimod 特别激活TLR7。 |
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Zhu, J., Lai, K., Bronile, R., et al.Porcine TLR8 and TLR7 are both activated by a selective TLR7 ligand, imiquimodMol. Immunol.45(11),3238-3243(2008)
Forward, N.A., Furlong, S.J., Yang, Y., et al.Signaling through TLR7 enhances the immunosuppressive activity of murine CD4+CD25+ T regulatory cellsJ. Leukoc. Biol.87(1),117-125(2010)
Velasquez, L.S., Hjelm, B.E., Arntzen, C.J., et al.An intranasally delivered Toll-like receptor 7 agonist elicits robust systemic and mucosal responses to Norwalk virus-like particlesClin. Vaccine Immunol.17(12),1850-1858(2010)
Buitendijk, M., Eszterhas, S.K., and Howell, A.L.Gardiquimod: A toll-like receptor-7 agonist that inhibits HIV type 1 infection of human macrophages and activated T cellsAIDS Res. Hum. Restroviruses29(6),907-918(2013)
Zou, B.B., Wang, F., Li, L., et al.Activation of Toll-like receptor 7 inhibits the proliferation and migration, and induces the apoptosis of pancreatic cancer cellsMol. Med. Rep.12(4),6079-6085(2015)
