Lefamulin
Cat. No.：YN251985
| 产品名称: | Lefamulin |
| CAS No.: | 1061337-51-6 |
| Chemical Name: | 2-[[(1R,2R,4R)-4-amino-2-hydroxycyclohexyl]thio]-acetic acid, (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester |
| Synonyms: | BC-3781 |
| 分子量: | 507.72664 |
| 分子式: | C28H45NO5S |
| SMILES: | O=C1CC[C@@]2(CC[C@H]3C)[C@@H](C)[C@H](O)[C@@](C=C)(C)C[C@@H](OC(CS[C@@H]4CC[C@@H](N)C[C@H]4O)=O)[C@@]3(C)[C@@]21[H] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Lefamulin (BC-3781) 是一种具有口服活性的抗生素 (antibiotic)。Lefamulin 通过与 50S 细菌核糖体的肽基转移酶peptidyl transferase中心结合来抑制蛋白质合成。Lefamulin 具有抗炎活性。Lefamulin 可用于研究细菌感染，如细菌性肺炎。 |
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Veve, M.P., and Wagner, J.L.Lefamulin: Review of a promising novel pleuromutilin antibioticPharmacotherapy38(9),935-946(2018)
Wicha, W.W., Craig, W.A., and Andes, D.In vivo pharmacodynamics of lefamulin, the first systemic pleuromutilin for human use, in a neutropenic murine thigh infection modelJ. Antimicrob. Chemother.74(Suppl 3),iii5-iii10(2019)
Hafner, M., Paukner, S., Wicha, W.W., et al.Anti-inflammatory activity of lefamulin versus azithromycin and dexamethasone in vivo and in vitro in a lipopolysaccharide-induced lung neutrophilia mouse modelPLoS One16(9),e0237659(2022)
