Setrobuvir
Cat. No.：YN251987
| 产品名称: | Setrobuvir |
| CAS No.: | 1071517-39-9 |
| Chemical Name: | N-[3-[(4aR,5S,8R,8aS)-1-[(4-Fluorophenyl)methyl]-1,2,4a,5,6,7,8,8a-octahydro-4-hydroxy-2-oxo-5,8-methanoquinolin-3-yl]-1,1-dioxido-2H-1,2,4-benzothiadiazin-7-yl]methanesulfonamide; |
| Synonyms: | ANA598 |
| 分子量: | 560.617603 |
| 分子式: | C25H25FN4O6S2 |
| SMILES: | [H][C@]12[C@](N(CC3=CC=C(F)C=C3)C(C(C(NC4=C5C=C(NS(C)(=O)=O)C=C4)=NS5(=O)=O)=C2O)=O)([H])[C@@H]6CC[C@H]1C6 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Setrobuvir (ANA598) 是一种口服活性的非核苷HCVNS5B聚合酶抑制剂。Setrobuvir 抑制 RNA 的从头合成 (RNA synthesis) 和引物延伸，IC50在 4~5 nM 之间。Setrobuvir 还显示出与 SARS-CoV-2RdRp的优异结合亲和力，并诱导 RdRp 抑制。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Netzler, N. E., et al.: Antimicrob. Agents Chemother., 63, 00003-19 (2019)
Nan, Y., et al.: Zhongguo Bingdubing Zazhi, 3, 468 (2013)
Mallalieu, N. L., et al.:Clin. Ther., 36, 2047 (2014)
