Nogalamycin
Cat. No.：YN252046
| 产品名称: | Nogalamycin |
| CAS No.: | 1404-15-5 |
| Chemical Name: | (2R,3S,4R,5R,6R,11S,13S,14R)-11-[(6-deoxy-3-C-methyl-2,3,4-tri-O-methyl-α-L-mannopyranosyl)oxy]-4-(dimethylamino)-3,4,5,6,9,11,12,13,14,16-decahydro-3,5,8,10,13-pentahydroxy-6,13-dimethyl-9,16-dioxo-2,6-epoxy-2H-naphthaceno[1,2-b]oxocin-14-carboxylic acid |
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| 分子量: | 787.8035 |
| 分子式: | C39H49NO16 |
| SMILES: | OC1=C(C(C(C(O)=CC2=C3O[C@@]4([H])[C@@H](O)[C@H](N(C)C)[C@@H](O)[C@@]2(O4)C)=C3C5=O)=O)C5=CC6=C1[C@@H](O[C@@]7([H])[C@H](OC)[C@@](OC)(C)[C@@H](OC)[C@H](C)O7)C[C@](C)(O)[C@@H]6C(OC)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Nogalamycin 是一种羟硝氨糖环素。Nogalamycin 是抗革兰氏阳性细菌的有效抗生素，对某些肿瘤细胞也具有细胞毒性。Nogalamycin 由Streptomyces nogalater var. Nogalater菌株产生。Nogalamycin 与 DNA 模板结合后选择性抑制 RNA 合成。可用于抗癌研究。 |
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Torkkell, S., Kunnari, T., Palmu, K., et al.Identification of a cyclase gene dictating the C-9 stereochemistry of anthracyclines from Streptomyces nogalaterAntimicrob. Agents Chemother.44(2),396-399(2000)
Neidle, S., Pearl, L.H., and Skelly, J.V.DNA structure and perturbation by drug bindingBiochem. J.243(1),1-13(1987)
Pradhan, A., and Tuteja, R.Plasmodium falciparum DNA helicase 60. dsRNA- and antibody-mediated inhibition of malaria parasite growth and downregulation of its enzyme activities by DNA-interacting compoundsFEBS J.273(15),3545-3556(2006)
Yakovleva, L., Handy, C.J., Sayer, J.M., et al.Benzo[c]phenanthrene adducts and nogalamycin inhibit DNA transesterification by vaccinia topoisomeraseJ. Biol. Chem.279(22),23335-23342(2004)
Dasgupta, H., Islam, M.S., Alam, N., et al.Induction of HRR genes and inhibition of DNMT1 is associated with anthracycline anti-tumor antibiotic-tolerant breast carcinoma cellsMol. Cell Biochem.453(1-2),163-178(2019)
