PB28 dihydrochloride
Cat. No.：YN252084
CAS No. ：172907-03-8
| 产品名称: | PB28 dihydrochloride |
| CAS No.: | 172907-03-8 |
| Chemical Name: | 1-cyclohexyl-4-[3-(1,2,3,4-tetrahydro-5-methoxy-1-naphthalenyl)propyl]-piperazine, dihydrochloride |
| Synonyms: | PB28 dihydrochloride |
| 分子量: | 443.49268 |
| 分子式: | C24H38N2O • 2HCl |
| SMILES: | COC1=CC=CC2=C1CCCC2CCCN3CCN(C4CCCCC4)CC3.Cl.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PB28 dihydrochloride，一种环己基哌嗪衍生物，是一种Ki值为 0.68 nM 的高亲和力和选择性sigma 2 (σ2)受体激动剂。PB28 dihydrochloride 也是一种σ1受体拮抗剂，Ki为 0.38 nM，对其他受体的亲和力较小。PB28 dihydrochloride 抑制豚鼠膀胱和回肠中的电诱发抽搐，其EC50值分别为 2.62 μM 和 3.96 μM。PB28 dihydrochloride 可以调节SARS-CoV-2-人之间的蛋白质与蛋白质的相互作用。PB28 |
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Azzariti, A., Colabufo, N.A., Beradi, F., et al.Cyclohexylpiperazine derivative PB28, a σ2 agonist and σ1 antagonist receptor, inhibits cell growth, modulates P-glycoprotein, and synergizes with anthracyclines in breast cancerMol. Cancer Ther.5(7),1807-1816(2006)
Gordon, D.E., Jang, G.M., Bouhaddou, M., et al.A SARS-CoV-2 protein interaction map reveals targets for drug repurposingNature583(7816),459-468(2020)
