Bofutrelvir
Cat. No.：YN252106
| 产品名称: | Bofutrelvir |
| CAS No.: | 2103278-86-8 |
| Chemical Name: | N-[(1S)-1-(cyclohexylmethyl)-2-[[(1S)-1-formyl-2-[(3S)-2-oxo-3-pyrrolidinyl]ethyl]amino]-2-oxoethyl]-1H-indole-2-carboxamide |
| Synonyms: | FB2001 |
| 分子量: | 452.6 |
| 分子式: | C25H32N4O4 |
| SMILES: | O=C1NCC[C@H]1C[C@H](NC([C@@H](NC(C2=CC(C=CC=C3)=C3N2)=O)CC4CCCCC4)=O)C=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Bofutrelvir (FB2001) 是 SARS-CoV-2 主要蛋白酶Mpro抑制剂，IC50值为 53 nM，EC50值为 0.53 μM。Bofutrelvir 对几种 SARS-CoV-2 变体具抗病毒作用，EC50值为 0.26-0.42 μM。Bofutrelvir 联合Remdesivir(HY-104077) 具有加性抗病毒作用。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Dai, W., Zhang, B., Jiang, X.-M., et al.Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main proteaseScience368(6497),1331-1335(2020)
