Vidarabine monohydrate
Cat. No.：YN252125
CAS No. ：23214-92-8
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| 产品名称: | Vidarabine monohydrate |
| CAS No.: | 23214-92-8 |
| Chemical Name: | |
| Synonyms: | 阿霉素; Hydroxydaunorubicin |
| 分子量: | 543.52 |
| 分子式: | C27H29NO11 |
| SMILES: | COC1=C2C(=O)C3=C(C(=C4CC(O)(CC(OC5CC(N)C(O)C(C)O5)C4=C3O)C(=O)CO)O)C(=O)C2=CC=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Doxorubicin (Hydroxydaunorubicin) 是一种有细胞毒性的蒽环类抗生素，常用作肿瘤化疗剂。Doxorubicin 抑制拓扑异构酶 II (topoisomerase-II)，IC50为 2.67 μM，从而抑制 DNA 复制。Doxorubicin 下调AMPK的基础磷酸化以及下游 acetyl-CoA 羧化酶。Doxorubicin 诱导凋亡 (apoptosis) 和自噬 (autophagy)。Doxorubicin 抑制人 DNA 拓扑异构酶 I (topoisomer |
| IC50和靶点: | [{name:"Topoisomerase I:0.8 μM (IC50)"},{name: "Topoisomerase II:2.67 μM (IC50)'}, 'Daunorubicins/Doxorubicins', 'HIV-1'] |
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| Clinical Trial: | |
| Solvent & Solubility: |
