PF-00835231
Cat. No.：YN252254
CAS No. ：870153-29-0
| 产品名称: | PF-00835231 |
| CAS No.: | 870153-29-0 |
| Chemical Name: | N-[(1S)-1-[[[(1S)-3-hydroxy-2-oxo-1-[[(3S)-2-oxo-3-pyrrolidinyl]methyl]propyl]amino]carbonyl]-3-methylbutyl]-4-methoxy-1H-indole-2-carboxamide |
| Synonyms: | Compound 5h (SARS-CoV-2 inhibitor) ;PF00835231;PF-00835231;PF 00835231 |
| 分子量: | 472.53424 |
| 分子式: | C24H32N4O6 |
| SMILES: | OCC([C@H](C[C@H]1C(NCC1)=O)NC([C@H](CC(C)C)NC(C2=CC3=C(OC)C=CC=C3N2)=O)=O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PF-00835231 是一种病毒主要蛋白酶3CLpro的抑制剂，对 SARS CoV-2 和 SARS CoV-1 3CLpro作用的IC50值分别为 0.27 nM 和 4 nM。PF-00835231 被开发用于抗 SARS-CoV-2/COVID-19 的研究。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Hoffman, R.L., Kania, R.S., Brothers, M.A., et al.Discovery of ketone-based covalent inhibitors of coronavirus 3CL proteases for the potential therapeutic treatment of COVID-19J. Med. Chem.63(21),12725-12747(2020)
