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CCT 137690

Cat. No.：1095382-05-0

  • CAS No. ：1095382-05-0

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    • 产品名称: CCT 137690
      CAS No.: 1095382-05-0
      Chemical Name:
      Synonyms:CCT137690
      分子量:551.48
      分子式:C₂₆H₃₁BrN₈O
      SMILES:CC1=CC(CN(CC2)CCN2C3=C4C(NC(C5=CC=C(N6CCN(C)CC6)C=C5)=N4)=NC=C3Br)=NO1
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 0.98
    • Bavetsias, V., Crumpler, S., Sun, C., et al.Optimization of imidazo[4,5-b]pyridine-based kinase inhibitors: Identification of a dual FLT3/Aurora kinase inhibitor as an orally bioavailable preclinical development candidate for the treatment of acute myeloid leukemiaJ. Med. Chem.55(20),8721-8734(2012)', 'Faisal, A., Vaughan, L., Bavetsias, V., et al.The aurora kinase inhibitor CCT137690 downregulates MYCN and sensitizes MYCN-amplified neuroblastoma in vivoMol. Cancer Ther.10(11),2115-2123(2011)', 'Moore, A.S., Faisal, A., Gonzalez de Castro, D., et al.Selective FLT3 inhibition of FLT3-ITD+ acute myeloid leukaemia resulting in secondary D835Y mutation: a model for emerging clinical resistance patternsLeukemia26(7),1462-1470(2012)', 'Wu, X., Liu, W., Cao, Q., et al.Inhibition of Aurora B by CCT137690 sensitizes colorectal cells to radiotherapyJ. Exp. Clin. Cancer Res.33,1-9(2014)
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