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A-1210477

Cat. No.：1668553-26-1

  • CAS No. ：1668553-26-1

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    • 产品名称: A-1210477
      CAS No.: 1668553-26-1
      Chemical Name:
      Synonyms:7-(1,3-Dimethyl-5-((4-(4-(methylsulfonyl)piperazin-1-yl)phenoxy)methyl)-1H-pyrazol-4-yl)-1-(2-morpholinoethyl)-3-(3-(naphthalen-1-yloxy)propyl)-1H-indole-2-carboxylic acid;7-[5-[[4-[4-[(Dimethylamino)sulfonyl]-1-piperazinyl]phenoxy]methyl]-1,3-dimethyl-1H
      分子量:850.04
      分子式:C₄₆H₅₅N₇O₇S
      SMILES:O=C(C(N1CCN2CCOCC2)=C(CCCOC3=C4C=CC=CC4=CC=C3)C5=C1C(C6=C(COC7=CC=C(N8CCN(S(=O)(N(C)C)=O)CC8)C=C7)N(C)N=C6C)=CC=C5)O
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 0.98
    • Leverson, J.D., Zhang, H., Chen, J., et al.Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax)Cell Death Dis.6,e1590(2015)', 'Bruncko, M., Wang, L., Sheppard, G.S., et al.Structure-guided design of a series of MCL-1 inhibitors with high affinity and selectivity.J. Med. Chem.58(5),2180-2194(2015)', "Opfeman, J.T.Attacking cancer's Achilles heel: Antagonism of anti-apoptotic BCL-2 family membersFEBS J.283(14),2661-2675(2016)
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