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C646

Cat. No.：328968-36-1

  • CAS No. ：328968-36-1

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    • 产品名称: C646
      CAS No.: 328968-36-1
      Chemical Name:
      Synonyms:C 646;C646 C-646 C 646;4-(4-((5-(4,5-Dimethyl-2-nitrophenyl)furan-2-yl)methylene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid;C-646;(Z)-4-(4-((5-(4,5-dimethyl-2-nitrophenyl)furan-2-yl)methylene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)ben
      分子量:445.42
      分子式:C₂₄H₁₉N₃O₆
      SMILES:O=C(O)C1=CC=C(N2N=C(C)/C(C2=O)=C\C3=CC=C(C4=CC(C)=C(C)C=C4[N+]([O-])=O)O3)C=C1
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 0.98
    • Bowers, E.M., Yan, G., Mukherjee, C., et al.Virtual ligand screening of the p300/CBP histone acetyltransferase: Identification of a selective small molecule inhibitorChem. Biol.17(5),471-482(2010)', 'Gao, X.n., Lin, J., Ning, Q.y., et al.A histone acetyltransferase p300 inhibitor C646 induces cell cycle arrest and apoptosis selectively in AML1-ETO-positive AML cellsPLoS One8(2),(2013)', 'Santer, F.R., Höschele, P.P.S., Oh, S.J., et al.Inhibition of the acetyltransferases p300 and CBP reveals a targetable function for p300 in the survival and invasion pathways of prostate cancer cell linesMol. Cancer Ther.10(9),1644-1655(2011)', 'Marek, R., Coelho, C.M., Sullivan, R.K.P., et al.Paradoxical enhancement of fear extinction memory and synaptic plasticity by inhibition of the histone acetyltransferase p300J. Neurosci.31(20),7486-7491(2011)', 'Crump, N.T., Hazzalin, C.A., Bowers, E.M., et al.Dynamic acetylation of all lysine-4 trimethylated histone H3 is evolutionarily conserved and mediated by p300/CBPProc. Natl. Acad. Sci. USA108(19),7814-7819(2011)
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