Romidepsin

Cat. No.：128517-07-7

CAS No. ：128517-07-7

产品名称:	Romidepsin
CAS No.:	128517-07-7
Chemical Name:
Synonyms:	罗米地辛; FK 228; FR 901228; NSC 630176
分子量:	540.70
分子式:	C₂₄H₃₆N₄O₆S₂
SMILES:	C/C=C(NC([C@@H](CSSCC/C=C/[C@@H](O1)CC2=O)NC([C@@H](C(C)C)N2)=O)=O)/C(N[C@@H](C(C)C)C1=O)=O
存储:	Please store the product under the recommended conditions in theCertificate of Analysis.
运输:	Room temperature in continental US; may vary elsewhere.

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Purity: 0.98

Nakajima, H., Kim, Y.B., Terano, H., et al.FR901228, a potent antitumor antibiotic, is a novel histone descetylase inhibitorExp. Cell Res.241(1),126-133(1998)', 'Wang, C., Henkes, L.M., Doughty, L.B., et al.Thailandepsins: Bacterial products with potent histone deacetylase inhibitory activities and broad-spectrum antiproliferative activitiesJ. Nat. Prod.74(10),2031-2038(2011)', 'Mazitschek, R., Patel, V., Wirth, D.F., et al.Development of a fluorescence polarization based assay for histone deacetylase ligand discoveryBioorg. Med. Chem. Lett.18(9),2809-2812(2008)', 'Ueda, H., Manda, T., Matsumoto, S., et al.FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. III. Antitumor activities on experimental tumors in miceJ. Antibiot. (Tokyo)47(3),315-323(1994)', 'VanderMolen, K.M., McCulloch, W., Pearce, C.J., et al.Romidepsin (Istodaxr, NSC 630176, FR901228, FK228, depsipeptide): A natural product recently approved for cutaneous T-cell lymphomaJ. Antibiot. (Tokyo)67(8),525-231(2015)', 'Coiffier, B., Federico, M., Caballero, D., et al.Therapeutic options in relapsed or refractory peripheral T-cell lymphomaCancer Treat. Rev.40(9),1080-1088(2014)', 'Qin, L., Ma, K., Wang, Z.-J., et al.Social deficits in Shank3-deficient mouse models of autism are rescued by histone deacetylase (HDAC) inhibitionNat. Neurosci.21(4),564-575(2018)