SecinH3
Cat. No.：YN270012
CAS No. ：853625-60-2
| 产品名称: | SecinH3 |
| CAS No.: | 853625-60-2 |
| Chemical Name: | N-[4-[5-(1,3-benzodioxol-5-yl)-3-methoxy-1H-1,2,4-triazol-1-yl]phenyl]-2-(phenylthio)-acetamide |
| Synonyms: | |
| 分子量: | 460.51 |
| 分子式: | C₂₄H₂₀N₄O₄S |
| SMILES: | O=C(NC1=CC=C(N2N=C(OC)N=C2C3=CC=C(OCO4)C4=C3)C=C1)CSC5=CC=CC=C5 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SecinH3 是cytohesins的拮抗剂，对于hCyh1，hCyh2，mCyh3，hCyh3，drosophila steppke和yGea2-S7的IC50值分别为 5.4 μM，2.4 μM，5.4 μM，5.6 μM，5.6 μM 和 65 μM。 |
| IC50和靶点: | |
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| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Kolanus, W.Guanine nucleotide exchange factors of the cytohesin family and their roles in signal transductionImmunol. Rev.218,102-113(2007)
Hafner, M., Schmitz, A., Grüne, I., et al.Inhibition of cytohesins by SecinH3 leads to hepatic insulin resistanceNature444(7121),941-944(2006)
Bi, X., Schmitz, A., Hayallah, A.M., et al.Affinity-based labeling of cytohesins with a bifunctional SecinH3 photoaffinity probeAngew. Chem. Int. Ed. Engl.47(49),9565-9568(2008)
Fuss, B., Becker, T., Zinke, I., et al.The cytohesin Steppke is essential for insulin signalling in DrosophilaNature444(7121),945-948(2006)
Pan, T., Sun, J., Hu, J., et al.Cytohesins/ARNO: The function in colorectal cancer cellsPLoS One9(3),e90997(2014)
