ROC-325
Cat. No.：YN270056
CAS No. ：1859141-26-6
| 产品名称: | ROC-325 |
| CAS No.: | 1859141-26-6 |
| Chemical Name: | 1-[[2-[[2-[(7-chloro-4-quinolinyl)amino]ethyl]methylamino]ethyl]amino]-4-methyl-9H-thioxanthen-9-one |
| Synonyms: | |
| 分子量: | 503.06 |
| 分子式: | C₂₈H₂₇ClN₄OS |
| SMILES: | O=C1C2=C(SC3=C1C=CC=C3)C(C)=CC=C2NCCN(CCNC4=CC=NC5=CC(Cl)=CC=C45)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | ROC-325 是一种有效的具有口服活性的自噬 (autophagy) 抑制剂，具有很强的抗癌活性。ROC-325 引起溶酶体脱酸，自噬体积累和自噬通量中断。ROC-325 还诱导肾细胞癌凋亡 (apoptosis)。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Carew, J.S., Espitia, C.M., Zhao, W., et al.Disruption of autophagic degradation with ROC-325 antagonizes renal cell carcinoma pathogenesisClin. Cancer Res.23(11),2869-2879(2017)
Gorshkov, K., Chen, C.Z., Bostwick, R., et al.The SARS-CoV-2 cytopathic effect is blocked by lysosome alkalizing small moleculesACS Infect. Dis.,(2020)
