DC661
Cat. No.：YN270104
CAS No. ：1872387-43-3
| 产品名称: | DC661 |
| CAS No.: | 1872387-43-3 |
| Chemical Name: | N6-(7-chloro-4-quinolinyl)-N1-[6-[(7-chloro-4-quinolinyl)amino]hexyl]-N1-methyl-1,6-hexanediamine |
| Synonyms: | DC661;N-(7-Chloroquinolin-4-yl)-N'-[6-[(7-chloroquinolin-4-yl)amino]hexyl]-N'-methylhexane-1,6-diamine;N1-(7-chloroquinolin-4-yl)-N6-(6-((7-chloroquinolin-4-yl)amino)hexyl)-N6-methylhexane-1,6-diamine;BCP30743;s8808;ZB1540 |
| 分子量: | 552.58 |
| 分子式: | C₃₁H₃₉Cl₂N₅ |
| SMILES: | CN(CCCCCCNC1=CC=NC2=CC(Cl)=CC=C12)CCCCCCNC3=CC=NC4=CC(Cl)=CC=C34 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | DC661 是一种有效的棕榈酰蛋白硫酯酶 1 (PPT1) 抑制剂，抑制自噬 (autophagy)，并作为抗溶酶体剂。具有抗肿瘤活性。 |
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Rebecca, V.W., Nicastri, M.C., Fennelly, C., et al.PPT1 promotes tumor growth and is the molecular target of chloroquine derivatives in cancerCancer Discov.9(2),220-229(2019)
Sharma, G., Ojha, R., Noguera-Ortega, E., et al.PPT1 inhibition enhances the antitumor activity of anti-PD-1 antibody in melanomaJCI Insight5(17),e133225(2020)
