DIM-C-pPhOH
Cat. No.：YN270111
CAS No. ：151358-47-3
| 产品名称: | DIM-C-pPhOH |
| CAS No.: | 151358-47-3 |
| Chemical Name: | 4-(di-1H-indol-3-ylmethyl)-phenol |
| Synonyms: | C-DIM8, CDIM8 |
| 分子量: | 338.40 |
| 分子式: | C₂₃H₁₈N₂O |
| SMILES: | OC1=CC=C(C(C2=CNC3=C2C=CC=C3)C4=CNC5=C4C=CC=C5)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | DIM-C-pPhOH 是核受体 4A1 (NR4A1) 拮抗剂。DIM-C-pPhOH 抑制癌细胞的生长和 mTOR 信号传导，诱导细胞凋亡和细胞应激。DIM-C-pPhOH 可降低细胞增殖，对 ACHN 细胞和 786-O 细胞的IC50值分别为 13.6 μM 和 13.0 μM。 |
| IC50和靶点: | |
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Chintharlapalli, S., Burghardt, R., Papineni, S., et al.Activation of Nur77 by selected 1,1-Bis(3'-indolyl)-1-(p-substituted phenyl)methanes induces apoptosis through nuclear pathwaysJ. Biol. Chem.280(26),24903-24914(2005)
Lee, S.-O., Abdelrahim, M., Yoon, K., et al.Inactivation of the orphan nuclear receptor TR3/Nur77 inhibits pancreatic cancer cell and tumor growthCancer Res.70(17),6824-6836(2010)
