Elesclomol
Cat. No.：YN270142
CAS No. ：488832-69-5
规格
价格(RMB)
库存
| 产品名称: | Elesclomol |
| CAS No.: | 488832-69-5 |
| Chemical Name: | 1,3-bis[2-methyl-2-(phenylthioxomethyl)hydrazide]-propanedioic acid |
| Synonyms: | STA-4783 |
| 分子量: | 400.52 |
| 分子式: | C₁₉H₂₀N₄O₂S₂ |
| SMILES: | S=C(C1=CC=CC=C1)N(NC(CC(NN(C(C2=CC=CC=C2)=S)C)=O)=O)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Elesclomol是一种氧化应激诱导剂，可诱导癌细胞凋亡。 |
| IC50和靶点: | |
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Kirshner, J.R., He, S., Balasubramanyam, V., et al.Elesclomol induces cancer cell apoptosis through oxidative stressMol. Cancer Ther.7(8),2319-2327(2008)
Nagai, M., Vo, N.H., Shin Ogawa, L., et al.The oncology drug elesclomol selectively transports copper to the mitochondria to induce oxidative stress in cancer cellsFree Radic. Biol. Med.52(10),2142-2150(2012)
Guthrie, L.M., Soma, S., Yuan, S., et al.Elesclomol alleviates Menkes pathology and mortality by escorting Cu to cuproenzymes in miceScience368(6491),620-625(2020)
