(5Z,2E)-CU-3
Cat. No.：YN270148
CAS No. ：1815598-71-0
| 产品名称: | (5Z,2E)-CU-3 |
| CAS No.: | 1815598-71-0 |
| Chemical Name: | N-[(5Z)-5-[(2E)-3-(2-furanyl)-2-propen-1-ylidene]-4-oxo-2-thioxo-3-thiazolidinyl]-benzenesulfonamide |
| Synonyms: | DGKα inhibitor CU-3 |
| 分子量: | 392.47 |
| 分子式: | C₁₆H₁₂N₂O₄S₃ |
| SMILES: | O=S(C1=CC=CC=C1)(NN(C/2=O)C(SC2=C/C=C/C3=CC=CO3)=S)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | (5Z,2E)-CU-3 是一种有效的选择性抗DGKα同工酶抑制剂，IC50值为 0.6 μM，竞争性抑制 DGKα 对 ATP 的亲和力，Km值为 0.48 mM。(5Z,2E)-CU-3 靶向 DGKα 催化区域，但不靶向调节区域。(5Z,2E)-CU-3 具有抗肿瘤和免疫原性作用，增强癌细胞的凋亡和 T 细胞的活化。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Liu, K., Kunii, N., Sakuma, M., et al.A novel diacylglycerol kinase α-selective inhibitor, CU-3, induces cancer cell apoptosis and enhances immune responseJ. Lipid Res.57(3),368-379(2016)
