NVP-2
Cat. No.：YN270151
CAS No. ：1263373-43-8
| 产品名称: | NVP-2 |
| CAS No.: | 1263373-43-8 |
| Chemical Name: | 4-[[[5′-chloro-2′-[[trans-4-[[(1R)-2-methoxy-1-methylethyl]amino]cyclohexyl]amino][2,4′-bipyridin]-6-yl]amino]methyl]tetrahydro-2H-pyran-4-carbonitrile |
| Synonyms: | NVP2;NVP 2;CDK9 inhibitor |
| 分子量: | 513.07 |
| 分子式: | C₂₇H₃₇ClN₆O₂ |
| SMILES: | ClC1=CN=C(N[C@H]2CC[C@H](N[C@H](C)COC)CC2)C=C1C3=CC=CC(NCC4(C#N)CCOCC4)=N3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | NVP-2 是一种有效且具有选择性的 ATP 竞争性细胞周期蛋白依赖性激酶 9 (CDK9) 探针，可抑制 CDK9/CycT 活性，IC50值为 0.514 nM。NVP-2 对 CDK1/CycB，CDK2/CycA 和 CDK16/CycY 激酶具有抑制作用，其IC50值分别为 0.584 µM，0.706 µM 和 0.605 µM。NVP-2诱导细胞凋亡 (apoptosis)。 |
| IC50和靶点: | [{name:"CDK9:0.5 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Olson, C.M., Jiang, B., Erb, M.A., et al.Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradationNat. Chem. Biol.14(2),163-170(2018)
