LY2857785
Cat. No.：YN270161
CAS No. ：1619903-54-6
| 产品名称: | LY2857785 |
| CAS No.: | 1619903-54-6 |
| Chemical Name: | trans-N1-[4-[2-methyl-3-(1-methylethyl)-2H-indazol-5-yl]-2-pyrimidinyl]-N4-(tetrahydro-2H-pyran-4-yl)-1,4-cyclohexanediamine |
| Synonyms: | LY 2857785;LY-2857785 |
| 分子量: | 448.60 |
| 分子式: | C₂₆H₃₆N₆O |
| SMILES: | CC(C1=C2C=C(C3=NC(N[C@H]4CC[C@H](NC5CCOCC5)CC4)=NC=C3)C=CC2=NN1C)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | LY2857785 是一种I型可逆的 ATP 竞争性的CDK9，CDK8和CDK7抑制剂，IC50分别为 11 nM，16 nM 和 246 nM。 |
| IC50和靶点: | [{name:"CDK9:0.011 μM (IC50)"},{name: "CDK8:0.016 μM (IC50)"},{name: "CDK7:0.246 μM (IC50)"}] |
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| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Yin, T., Lallena, M.J., Kreklau, E.L., et al.A novel CDK9 inhibitor shows potent antitumor efficacy in preclinical hematologic tumor modelsMol. Cancer Ther.13(6),1442-1456(2014)
