CDKI-73
Cat. No.：YN270170
CAS No. ：1421693-22-2
| 产品名称: | CDKI-73 |
| CAS No.: | 1421693-22-2 |
| Chemical Name: | |
| Synonyms: | LS-007 |
| 分子量: | 394.45 |
| 分子式: | C₁₅H₁₅FN₆O₂S₂ |
| SMILES: | CNC1=NC(C)=C(C2=C(F)C=NC(NC3=CC(S(=O)(N)=O)=CC=C3)=N2)S1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CDKI-73 (LS-007) 是具有口服活性的、高效的CDK9抑制剂，其对CDK9、CDK1 和 CDK2 的Ki值分别为 4 nM、4 nM 和 3 nM。CDKI-73 可下调 RNA 聚合酶 II 的磷酸化。CDKI-73 也是一种 Rab11 的抑制剂。 |
| IC50和靶点: | [{name:"CDK2:3.27 nM (IC50)"},{name: "CDK9:5.78 nM (IC50)"},{name: "CDK1:8.17 nM (IC50)"},{name: "CDK4:8.18 nM (IC50)"},{name: "CDK6:37.68 nM (IC50)"},{name: "CDK7:134.26 nM (IC50)"},{name: "CDK1:4 nM (Ki)"},{name: "CDK2:3 nM (Ki)"},{name: "CDK9:4 nM (Ki)"},{name: "CDK7:91 nM (Ki)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
