AZD5582
Cat. No.：YN270189
| 产品名称: | AZD5582 |
| CAS No.: | 1258392-53-8 |
| Chemical Name: | 3,3′-[2,4-hexadiyne-1,6-diylbis[oxy[(1S,2R)-2,3-dihydro-1H-indene-2,1-diyl]]]bis[N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl-L-prolinamide |
| Synonyms: | 3,3'-[2,4-Hexadiyne-1,6-diylbis[oxy[(1S,2R)-2,3-dihydro-1H-indene-2,1-diyl]]]bis[N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl-L-prolinamide];AZD5582;AZD 5582;GTPL7710;AOB5560;(2S)-1-[(2S)-2-cyclohexyl-2-[[(2S)-2-(methylamino)propanoyl]amino]acetyl]-N-[(1S,2R |
| 分子量: | 1015.29 |
| 分子式: | C₅₈H₇₈N₈O₈ |
| SMILES: | CN[C@@H](C)C(N[C@H](C(N1[C@H](C(N[C@H]2C3=CC=CC=C3C[C@H]2OCC#CC#CCO[C@H]4[C@@H](NC([C@@H]5CCCN5C([C@@H](NC([C@H](C)NC)=O)C6CCCCC6)=O)=O)C(C=CC=C7)=C7C4)=O)CCC1)=O)C8CCCCC8)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AZD5582 是IAP拮抗剂，可以有效与 cIAP1，cIAP2 和 XIAP 的 BIR3 结构域结合,IC50值分别为 15，21，15 nM。AZD5582 诱导凋亡 (apoptosis)。 |
| IC50和靶点: | [{name:"cIAP1:15 nM (IC50)"},{name: "cIAP2:21 nM (IC50)"},{name: "XIAP:15 nM (IC50)"}] |
| In Vitro: | |
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| Solvent & Solubility: |
Hennessy, E.J., Adam, A., Aquila, B.M., et al.Discovery of a novel class of dimeric Smac mimetics as potent IAP antagonists resulting in a clinical candidate for the treatment of cancer (AZD5582)J. Med. Chem.56(24),9897-9919(2013)
Nixon, C.C., Mavigner, M., Sampey, G.C., et al.Systemic HIV and SIV latency reversal via non-canonical NF-κB signalling in vivoNature578(7793),160-165(2020)
