SP2509
Cat. No.：YN270191
CAS No. ：1423715-09-6
| 产品名称: | SP2509 |
| CAS No.: | 1423715-09-6 |
| Chemical Name: | 3-(4-morpholinylsulfonyl)-benzoic acid (2E)-2-[1-(5-chloro-2-hydroxyphenyl)ethylidene]hydrazide |
| Synonyms: | HCI-2509 |
| 分子量: | 437.90 |
| 分子式: | C₁₉H₂₀ClN₃O₅S |
| SMILES: | O=C(N/N=C(C1=CC(Cl)=CC=C1O)\C)C2=CC=CC(S(=O)(N3CCOCC3)=O)=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SP2509 是有效，选择性的LSD1拮抗剂，IC50值为 13 nM。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Forneris, F., Binda, C., Vanoni, M.A., et al.Human histone demethylase LSD1 reads the histone codeJ. Biol. Chem.280(50),41360-41365(2005)
Fiskus, W., Sharma, S., Abhyankar, S., et al.Pre-clinical efficacy of combined therapy with LSD1 antagonist SP-2509 and pan-histone deacetylase inhibitor against AML blast progenitor cells,1-1()
Fiskus, W., Sharma, S., Shah, B., et al.Highly effective combination of LSD1 (KDM1A) antagonist and pan-histone deacetylase inhibitor against human AML cellsLeukemia28(11),2155-2164(2014)
