Pracinostat
Cat. No.：YN270222
CAS No. ：929016-96-6
| 产品名称: | Pracinostat |
| CAS No.: | 929016-96-6 |
| Chemical Name: | 3-[2-butyl-1-[2-(diethylamino)ethyl]-1H-benzimidazol-5-yl]-N-hydroxy-2E-propenamide |
| Synonyms: | SB939 |
| 分子量: | 358.48 |
| 分子式: | C₂₀H₃₀N₄O₂ |
| SMILES: | ONC(/C=C/C1=CC=C2N(C(CCCC)=NC2=C1)CCN(CC)CC)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Pracinostat 是一种有效的组蛋白去乙酰化酶 (HDAC) 抑制剂，对 HDACs 的IC50值为 40-140 nM，可用于癌症研究。 |
| IC50和靶点: | [{name:"HDAC10:40 nM (IC50)"},{name: "HDAC3:43 nM (IC50)"},{name: "HDAC5:47 nM (IC50)"},{name: "HDAC1:49 nM (IC50)"},{name: "HDAC4:56 nM (IC50)"},{name: "HDAC9:70 nM (IC50)"},{name: "HDAC11:93 nM (IC50)"},{name: "HDAC2:96 nM (IC50)"},{name: "HDAC7:137 nM (IC50)"},{name: "HDAC8:140 nM (IC50)"},{name: "HDAC6:1008 nM (IC50)"},{name: "MBLAC2:<10 nM (EC50)"}] |
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Wang, H., Yu, N., Chen, D., et al.Discovery of (2E)-3-{2-butyl-1-[2-diethylamino)ethyl]-1H-benzamidazol-5-yl}-N-hydroxyacrylamide (SB939), an orally active histone deacetylase inhibitor with a superior preclinical profileJ. Med. Chem.54(13),4694-4720(2011)
Novotny-Diermayr, V., Hart, S., Goh, K.C., et al.The oral HDAC inhibitor pracinostat (SB939) is efficacious and synergistic with the JAK2 inhibitor pacritinib (SB1518) in preclinical models of AMLBlood Cancer J.2(5),1-10(2012)
