β-Lapachone
Cat. No.：YN270235
CAS No. ：4707-32-8
| 产品名称: | β-Lapachone |
| CAS No.: | 4707-32-8 |
| Chemical Name: | 3,4-dihydro-2,2-dimethyl-2H-naphtho[1,2-b]pyran-5,6-dione |
| Synonyms: | ARQ-501; NSC-26326 |
| 分子量: | 242.27 |
| 分子式: | C₁₅H₁₄O₃ |
| SMILES: | O=C(C1=C2OC(C)(C)CC1)C(C3=C2C=CC=C3)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | β-Lapachone (ARQ-501;NSC-26326) 是一种天然的萘醌类化合物，是拓扑异构酶 I (topoisomerase I) 抑制剂，通过抑制细胞周期进程来诱导细胞凋亡。 |
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Li, C.J., Averboukh, L., and Pardee, A.B.β-Lapachone, a novel DNA topoisomerase I inhibitor with a mode of action different from camptothecinJ. Biol. Chem.268(30),22463-22468(1993)
Lai, T.-S., Liu, Y., Tucker, T., et al.Identification of chemical inhibitors to human tissue transglutaminase by screening existing drug librariesChem. Biol.15(9),969-978(2008)
Siegel, D., Yan, C., and Ross, D.NAD(P)H:quinone oxidoreductase 1 (NQO1) in the sensitivity and resistance to antitumor quinonesBiochem. Pharmacol.83(8),1033-1040(2012)
Dong, G.Z., Oh, E.T., Lee, H., et al.β-Lapachone suppresses radiation-induced activation of nuclear factor-κBExp. Mol. Med.42(5),327-334(2010)
Li, L.S., Bey, E.A., Dong, Y., et al.Modulating endogenous NQO1 levels identifies key regulatory mechanisms of action of β-lapachone for pancreatic cancer therapyClin. Cancer Res.17,275-285(2011)
