Cladribine
Cat. No.：YN270243
CAS No. ：4291-63-8
| 产品名称: | Cladribine |
| CAS No.: | 4291-63-8 |
| Chemical Name: | 2-chloro-2'-deoxy-adenosine |
| Synonyms: | 克拉屈滨; 2-Chloro-2′-deoxyadenosine; CldAdo; 2CdA |
| 分子量: | 285.69 |
| 分子式: | C₁₀H₁₂ClN₅O₃ |
| SMILES: | OC[C@@H]1[C@H](C[C@H](N2C=NC3=C2N=C(Cl)N=C3N)O1)O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Cladribine (2CdA) 是一种嘌呤核苷类似物，是具有口服活性的腺苷脱氨酶 (adenosine deaminase) 抑制剂。Cladribine 能作为 DNA 合成 (DNA synthesis) 的抑制剂，可阻断受损 DNA 的修复。Cladribine 可以抑制 DNA 甲基化。Cladribine 具有抗淋巴瘤活性，可用于一些血液恶性肿瘤和多发性硬化的研究。 |
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Hermann, R., Krajcsi, P., Fluck, M., et al.Cladribine as a potential object of nucleoside transporter‑based drug interactionsClin. Pharmacokinet.,(2021)
Carson, D.A., Wasson, D.B., Taetle, R., et al.Specific toxicity of 2-chlorodeoxyadenosine toward resting and proliferating human lymphocytesBlood62(4),737-743(1983)
Seto, S., Carrera, C.J., Kubota, M., et al.Mechanism of deoxyadenosine and 2-chlorodeoxyadenosine toxicity to nondividing human lymphocytesJ. Clin. Invest.75(2),377-383(1985)
Ma, J., Wang, S., Zhao, M., et al.Therapeutic potential of cladribine in combination with STAT3 inhibitor against multiple myelomaBMC Cancer11,255(2011)
Bagley, R.G., Roth, S., Kurtzberg, L.S., et al.Bone marrow CFU-GM and human tumor xenograft efficacy of three antitumor nucleoside analogsInt. J. Oncol.34(5),1329-1340(2009)
